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Article

Unliganded gating of acetylcholine receptor channels.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2009

Purohit Prasad, Auerbach Anthony

Abstract excerpt

We estimated the unliganded opening and closing rate constants of neuromuscular acetylcholine receptor-channels (AChRs) having mutations that increased the gating equilibrium constant. For some mutant combinations, spontaneous openings occurred in clusters. For 25 different constructs, the unliganded gating equilibrium constant (E(0)) was correlated with the product of the predicted fold-increase in the...

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Identifiers

PMID: 19114650
DOI: 10.1073/pnas.0809272106
PMCID: PMC2629231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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