Article
Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.
PloS one - 28 Nov 2007
Lee Soyoung, Horn Virginie, Julien Eric, Liu Yi, Wysocka Joanna, Bowerman Bruce, Hengartner Michael O, Herr Winship
Abstract excerpt
BACKGROUND: The human herpes simplex virus (HSV) host cell factor HCF-1 is a transcriptional coregulator that associates with both histone methyl- and acetyltransferases, and a histone deacetylase and regulates cell proliferation and division. In HSV-infected cells, HCF-1 associates with the viral protein VP16 to promote formation of a multiprotein-DNA transcriptional activator complex. The ability of HCF...
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