Next-Generation Sequencing of <i>Plasmodium vivax</i> Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes

Abstract excerpt

Understanding the mechanisms of drug resistance in Plasmodium vivax, the parasite that causes the most widespread form of human malaria, is complicated by the lack of a suitable long-term cell culture system for this parasite. In contrast to P. falciparum, which can be more readily manipulated in the laboratory, insights about parasite biology need to be inferred from human studies. Here we analyze the genomes of...

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