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Article

Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway.

Cell death and differentiation - 1 Apr 1998

Sawamoto K, Taguchi A, Hirota Y, Yamada C, Jin M H, Okano H

Abstract excerpt

We studied the role of Ras signaling in the regulation of cell death during Drosophila eye development. Overexpression of Argos, a diffusible inhibitor of the EGF receptor and Ras signaling, caused excessive cell death in developing eyes at pupal stages. The Argos-induced cell death was suppressed by coexpression of the anti-apoptotic genes p35, diap1, or diap2 in the eye as well as by the Df(3L)H99 chromosomal...

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PMID: 10200472
DOI: 10.1038/sj.cdd.4400342

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EGF

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