Article
Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure (London, England : 1993) - 15 Jun 1998
Varghese J N, Smith P W, Sollis S L, Blick T J, Sahasrabudhe A, McKimm-Breschkin J L, Colman P M
Abstract excerpt
BACKGROUND: Inhibitors of the influenza virus neuraminidase have been shown to be effective antiviral agents in humans. Several studies have reported the selection of novel influenza strains when the virus is cultured with neuraminidase inhibitors in vitro. These resistant viruses have mutations...
Topics
- Antiviral Agents
- Arginine
- Drug Design
- Drug Resistance, Microbial
- Influenza A virus
- Mutation
- Neuraminidase