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Article

Platform for determining the inhibition profile of neuraminidase inhibitors in an influenza virus N1 background.

Journal of virological methods - 1 Nov 2016

Hoffmann Anja, Schade Dennis, Kirchmair Johannes, Clement Bernd, Sauerbrei Andreas, Schmidtke Michaela

Abstract excerpt

Efforts to develop novel neuraminidase inhibitors (NAIs) for the treatment of influenza are ongoing. Novel NAIs should in particular be also effective against seasonal and/or pandemic N1 that carry a H274Y or N294S substitution (N2 numbering), which are most commonly linked to oseltamivir resistance. Here we report a platform for profiling the efficacy of novel NAIs in the N1 genetic background of influenza A...

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Source

Identifiers

PMID: 27659246
DOI: 10.1016/j.jviromet.2016.09.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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