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Article

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.

Nature - 7 Sept 2006

Russell Rupert J, Haire Lesley F, Stevens David J, Collins Patrick J, Lin Yi Pu, Blackburn G Michael, Hay Alan J, Gamblin Steven J, Skehel John J

Abstract excerpt

The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the ability to pass readily among humans and cause a pandemic. Two anti-influenza drugs currently being used to treat infected patients are oseltamivir (Tamiflu) and zanamivir (Relenza), both of which target the neuraminidase enzyme of the virus. Reports of the emergence of drug resistance make the development of new...

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Identifiers

PMID: 16915235
DOI: 10.1038/nature05114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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