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Article

Structural studies of the resistance of influenza virus neuramindase to inhibitors.

Journal of medicinal chemistry - 23 May 2002

Smith Brian J, McKimm-Breshkin Jennifer L, McDonald Mandy, Fernley Ross T, Varghese Joseph N, Colman Peter M

Abstract excerpt

Zanamivir and oseltamivir, specific inhibitors of influenza virus neuraminidase, have significantly different characteristics in resistance studies. In both cases resistance is known to arise through mutations in either the hemagglutinin or neuraminidase surface proteins. A new inhibitor under development by Biocryst Pharmaceuticals, BCX-1812, has both a guanidino group, as in zanamivir, and a bulky hydrophobic...

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Identifiers

PMID: 12014958
DOI: 10.1021/jm010528u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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