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Article

Fringe forms a complex with Notch.

Nature - 11 May 2000

Ju B G, Jeong S, Bae E, Hyun S, Carroll S B, Yim J, Kim J

Abstract excerpt

The Fringe protein of Drosophila and its vertebrate homologues function in boundary determination during pattern formation. Fringe has been proposed to inhibit Serrate-Notch signalling but to potentiate Delta-Notch signalling. Here we show that Fringe and Notch form a complex through both the Lin-Notch repeats and the epidermal growth factor repeats 22-36 (EGF22-36) of Notch when they are co-expressed. The...

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Source

Identifiers

PMID: 10821276
DOI: 10.1038/35012090

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Fringe forms a complex with Notch.PMID 10821276Read ↗

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