Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.

doi:10.1038/ng0197-106

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Article

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.

Nature genetics - 1 Jan 1997

Stoffers D A, Zinkin N T, Stanojevic V, Clarke W L, Habener J F

Abstract excerpt

The homeodomain protein IPF1 (also known as IDX1, STF1 and PDX1; see Methods) is critical for development of the pancreas in mice and is a key factor for the regulation of the insulin gene in the beta-cells of the endocrine pancreas. Targeted disruption of the Ipf1 gene encoding IPF1 in transgeni...

Topics

Amino Acid Sequence
Animals
Base Sequence
COS Cells
Cloning, Molecular
Codon
Cytosine
DNA
Female
Frameshift Mutation
Genotype
Homeodomain Proteins
Humans
Infant, Newborn
Molecular Sequence Data
Pancreas
Pedigree
Point Mutation

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