Article
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.
Nature genetics - 1 Jan 1997
Stoffers D A, Zinkin N T, Stanojevic V, Clarke W L, Habener J F
Abstract excerpt
The homeodomain protein IPF1 (also known as IDX1, STF1 and PDX1; see Methods) is critical for development of the pancreas in mice and is a key factor for the regulation of the insulin gene in the beta-cells of the endocrine pancreas. Targeted disruption of the Ipf1 gene encoding IPF1 in transgenic mice results in a failure of the pancreas to develop (pancreatic agenesis). Here, we report the identification of a...
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