Article
Incidence of DNA replication errors in patients with multiple primary cancers.
Diseases of the colon and rectum - 1 Jun 1998
Brown S R, Finan P J, Hall N R, Bishop D T
Abstract excerpt
PURPOSE: Multiple primary cancers are a feature of hereditary nonpolyposis colorectal cancer in which defects in DNA repair mechanisms result in accumulation of replication errors within tumor DNA. We assessed replication error incidence in multiple primary cancer patients who may have similar ge...
Topics
- Aged
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Replication
- DNA, Neoplasm
- Electrophoresis, Polyacrylamide Gel
- Humans
- Microsatellite Repeats
- Middle Aged
- Neoplasms, Multiple Primary
- Phenotype
- Polymerase Chain Reaction