Genetic rescue of follicle-stimulating hormone beta-deficient mice.

doi:10.1210/endo.139.7.6111

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Article

Genetic rescue of follicle-stimulating hormone beta-deficient mice.

Endocrinology - 1 Jul 1998

Kumar T R, Low M J, Matzuk M M

Abstract excerpt

FSH is an alpha:beta heterodimeric pituitary glycoprotein that shares a common alpha-subunit with LH and TSH. To study the role of FSH in mammalian reproduction, we have previously generated an FSH-deficient mouse model using embryonic stem (ES) cell technology by introducing a null mutation in t...

Topics

Animals
Female
Fertility
Follicle Stimulating Hormone
Follicle Stimulating Hormone, beta Subunit
Gene Transfer Techniques
Humans
Male
Mice
Mice, Transgenic
Phenotype
Pituitary Gland, Anterior
Sex Characteristics
Transgenes

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