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Article

Genetic rescue of follicle-stimulating hormone beta-deficient mice.

Endocrinology - 1 Jul 1998

Kumar T R, Low M J, Matzuk M M

Abstract excerpt

FSH is an alpha:beta heterodimeric pituitary glycoprotein that shares a common alpha-subunit with LH and TSH. To study the role of FSH in mammalian reproduction, we have previously generated an FSH-deficient mouse model using embryonic stem (ES) cell technology by introducing a null mutation in the unique FSHbeta gene. Male mice deficient in FSH are fertile despite their small testes and reduced sperm number and...

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Identifiers

PMID: 9645705
DOI: 10.1210/endo.139.7.6111

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