Article
Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998
Dierich A, Sairam M R, Monaco L, Fimia G M, Gansmuller A, LeMeur M, Sassone-Corsi P
Abstract excerpt
Pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone stimulate the gonads by regulating germ cell proliferation and differentiation. FSH receptors (FSH-Rs) are localized to testicular Sertoli cells and ovarian granulosa cells and are coupled to activation of the aden...
Topics
- Animals
- Female
- Follicle Stimulating Hormone
- Gene Expression Regulation
- Granulosa Cells
- Humans
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Receptors, FSH