Article
Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998
Dierich A, Sairam M R, Monaco L, Fimia G M, Gansmuller A, LeMeur M, Sassone-Corsi P
Abstract excerpt
Pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone stimulate the gonads by regulating germ cell proliferation and differentiation. FSH receptors (FSH-Rs) are localized to testicular Sertoli cells and ovarian granulosa cells and are coupled to activation of the adenylyl cyclase and other signaling pathways. Activation of FSH-Rs is considered essential for folliculogenesis in the...
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