Article
Mouse models for gonadotropins: a 15-year saga.
Molecular and cellular endocrinology - 2 Jan 2007
Kumar T Rajendra
Abstract excerpt
Pituitary gonadotropins FSH and LH are heterodimeric glycoproteins consisting of a common alpha and a hormone-specific beta subunit that are non-covalently linked. Both these hormones bind G-protein coupled receptors and regulate multiple processes in the gonads. Advances in the past two decades in manipulating the mouse genome by random and site-specific mutagenesis have been invaluable to our understanding of...
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