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Article

Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2014

Fortin Jérôme, Boehm Ulrich, Deng Chu-Xia, Treier Mathias, Bernard Daniel J

Abstract excerpt

Follicle-stimulating hormone (FSH) is an essential regulator of gonadal function and fertility. Loss-of-function mutations in the FSHB/Fshb gene cause hypogonadotropic hypogonadism in humans and mice. Both gonadotropin-releasing hormone (GnRH) and activins, members of the transforming growth factor β (TGFβ) superfamily, stimulate FSH synthesis; yet, their relative roles and mechanisms of action in vivo are...

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Source

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Identifiers

PMID: 24739304
DOI: 10.1096/fj.14-249532
PMCID: PMC4101660

Genes

SMAD4
FOXL2
FSHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.PMID 24739304Read ↗

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Regulation of the ovarian reserve by members of the transforming growth factor beta familySemantic proximity Read ↗

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