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Human Follicle-Stimulating Hormone ß Subunit Expression Depends on FOXL2 and SMAD4

12 Mar 2020

Abstract excerpt

Follicle-stimulating hormone (FSH), an essential regulator of mammalian fertility, is synthesized by pituitary gonadotrope cells in response to activins. In mice, activins signal via SMAD3, SMAD4, and FOXL2 to regulate transcription of the FSHβ subunit (Fshb) gene. Gonadotrope-specific deletion of Foxl2, alone or in combination with Smad4, renders mice FSH-deficient. Whether human FSHB expression is similarly...

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PMID: 32191302
DOI: 10.1210/endocr/bqaa045

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