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Article

The molecular basis of impaired follicle-stimulating hormone action: evidence from human mutations and mouse models.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Mar 2013

Siegel Eric T, Kim Hyung-Goo, Nishimoto Hiromi Koso, Layman Lawrence C

Abstract excerpt

The pituitary gonadotropin follicle-stimulating hormone (FSH) interacts with its membrane-bound receptor to produce biologic effects. Traditional functions of FSH include follicular development and estradiol production in females, and the regulation of Sertoli cell action and spermatogenesis in males. Knockout mice for both the ligand (Fshb) and the receptor (Fshr) serve as models for FSH deficiency, while Fshb...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23184658
DOI: 10.1177/1933719112461184
PMCID: PMC3823505

Genes

FSHR
FSHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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