Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Activated Human Follicle-Stimulating Hormone (FSH) Receptor Stimulates FSH-Like Activity in Gonadotropin-Deficient Transgenic Mice

28 Oct 2002

Abstract excerpt

FSH mediates its testicular actions via a specific Sertoli cell G protein-coupled receptor. We created a novel transgenic model to investigate a mutant human FSH receptor (FSHR(+)) containing a single amino acid substitution (Asp567Gly) equivalent to activating mutations in related glycoprotein hormone receptors. To examine the ligand-independent gonadal actions of FSHR(+), the rat androgen-binding protein gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ovarian function and disorders
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12403847
DOI: 10.1210/me.2002-0032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Activated Human Follicle-Stimulating Hormone (FSH) Receptor Stimulates FSH-Like Activity in Gonadotropin-Deficient Transgenic MicePMID 12403847Read ↗

Transgenic mutant D567G but not wild-type human FSH receptor overexpression provides FSH-independent and promiscuous glycoprotein hormone Sertoli cell signaling.Semantic proximity Read ↗

A Novel Transgenic Model to Characterize the Specific Effects of Follicle-Stimulating Hormone on Gonadal Physiology in the Absence of Luteinizing Hormone Actions*Semantic proximity Read ↗

The molecular basis of impaired follicle-stimulating hormone action: evidence from human mutations and mouse models.Semantic proximity Read ↗

Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess.Semantic proximity Read ↗

Maintenance of spermatogenesis by the activated human (Asp567Gly) FSH receptor during testicular regression due to hormonal withdrawal.Semantic proximity Read ↗

Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance.Semantic proximity Read ↗

Mutations of follicle stimulating hormone-beta and its receptor in human and mouse: genotype/phenotype.Semantic proximity Read ↗

Mouse models for gonadotropins: a 15-year saga.Semantic proximity Read ↗

An overview of FSH-FSHR biology and explaining the existing conundrumsSemantic proximity Read ↗

Molecular regulation of follicle-stimulating hormone synthesis, secretion and actionSemantic proximity Read ↗

The role of follicle-stimulating hormone in spermatogenesis: lessons from knockout animal models.Semantic proximity Read ↗

Molecular pathology of the FSH receptor: new insights into FSH physiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.