Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

Abstract excerpt

Calcineurin is a calcium-dependent protein phosphatase that functions in T cell activation. We present evidence that calcineurin functions more generally in calcium-triggered apoptosis in mammalian cells deprived of growth factors. Specifically, expression of epitope-tagged calcineurin A induces rapid cell death upon calcium signaling in the absence of growth factors. We show that this apoptosis does not require...

Topics

• Animals
• Apoptosis
• Calcineurin
• Calcium
• Calmodulin-Binding Proteins
• Cell Line
• Cricetinae
• Gene Expression
• Growth Substances
• Kidney
• Mutation
• Phosphoprotein Phosphatases