Article
Calcineurin activation protects T cells from glucocorticoid-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995
Zhao Y, Tozawa Y, Iseki R, Mukai M, Iwata M
Abstract excerpt
In T cell hybridomas, TCR/CD3 complex-mediated stimulation induces apoptosis but inhibits that induced by glucocorticoids. A combination of ionomycin (IM), a calcium ionophore, and PMA, a protein kinase C activator, mimics the effects of the TCR/CD3-mediated stimulation. Glucocorticoid-induced apoptosis is, however, markedly inhibited by IM alone, and less markedly by PMA alone. The immunosuppressant FK506...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.