Calcineurin activation protects T cells from glucocorticoid-induced apoptosis.

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Article

Calcineurin activation protects T cells from glucocorticoid-induced apoptosis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995

Zhao Y, Tozawa Y, Iseki R, Mukai M, Iwata M

Abstract excerpt

In T cell hybridomas, TCR/CD3 complex-mediated stimulation induces apoptosis but inhibits that induced by glucocorticoids. A combination of ionomycin (IM), a calcium ionophore, and PMA, a protein kinase C activator, mimics the effects of the TCR/CD3-mediated stimulation. Glucocorticoid-induced apoptosis is, however, markedly inhibited by IM alone, and less markedly by PMA alone. The immunosuppressant FK506...

Topics

Animals
Apoptosis
Base Sequence
Calcineurin
Calcium
Calmodulin-Binding Proteins
DNA, Complementary
Dexamethasone
Drug Interactions
Hybridomas
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ionomycin

Lymphocyte Activation

Male

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 7539018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7539018-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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