Article
A nickel complex cleaves uridine in folded RNA structures: application to E. coli tmRNA and related engineered molecules.
Journal of molecular biology - 12 Jun 1998
Hickerson R P, Watkins-Sims C D, Burrows C J, Atkins J F, Gesteland R F, Felden B
Abstract excerpt
To gain more insight about Escherichia coli tmRNA structure, NiCR, a square planar macrocyclic nickel (II) complex, was used to probe guanine N7 exposure. On the basis of this additional structural information, a refined secondary structure of the molecule is proposed. In addition to its known sp...
Topics
- Base Composition
- Base Sequence
- Escherichia coli
- Free Radicals
- Guanine
- Magnesium
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Nickel
- Nucleic Acid Conformation
- Oligoribonucleotides
- Organometallic Compounds
- RNA, Bacterial
- Sulfuric Acid Esters
- Uridine