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Article

A nickel complex cleaves uridine in folded RNA structures: application to E. coli tmRNA and related engineered molecules.

Journal of molecular biology - 12 Jun 1998

Hickerson R P, Watkins-Sims C D, Burrows C J, Atkins J F, Gesteland R F, Felden B

Abstract excerpt

To gain more insight about Escherichia coli tmRNA structure, NiCR, a square planar macrocyclic nickel (II) complex, was used to probe guanine N7 exposure. On the basis of this additional structural information, a refined secondary structure of the molecule is proposed. In addition to its known specificity for guanine N7, we show here that the chemical probe can also cleave at specific uridine residues. In...

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Identifiers

PMID: 9641979
DOI: 10.1006/jmbi.1998.1813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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