Article
A contact photo-cross-linking investigation of the active site of the 8-17 deoxyribozyme.
Journal of molecular biology - 12 Sept 2008
Liu Yong, Sen Dipankar
Abstract excerpt
The small RNA-cleaving 8-17 deoxyribozyme (DNAzyme) has been the subject of extensive mechanistic and structural investigation, including a number of recent single-molecule studies of its global folding. Little detailed insight exists, however, into this DNAzyme's active site; for instance, the identity of specific nucleotides that are proximal to or in contact with the scissile site in the substrate. Here, we...
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