Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.

Article

Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.

Blood - 1 Jul 1998

Side L E, Emanuel P D, Taylor B, Franklin J, Thompson P, Castleberry R P, Shannon K M

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a pediatric myelodysplastic syndrome that is associated with neurofibromatosis, type 1 (NF1). The NF1 tumor suppressor gene encodes neurofibromin, which regulates the growth of immature myeloid cells by accelerating guanosine triphosphate hydrolysis on R...

Topics

Child, Preschool
Female
Humans
Infant
Leukemia, Myelomonocytic, Chronic
Male
Mutation
Myelodysplastic Syndromes
Neurofibromatosis 1
Neurofibromin 1
Proteins

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