Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.

Blood - 1 Jul 1998

Side L E, Emanuel P D, Taylor B, Franklin J, Thompson P, Castleberry R P, Shannon K M

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a pediatric myelodysplastic syndrome that is associated with neurofibromatosis, type 1 (NF1). The NF1 tumor suppressor gene encodes neurofibromin, which regulates the growth of immature myeloid cells by accelerating guanosine triphosphate hydrolysis on Ras proteins. The purpose of this study was to determine if the NF1 gene was involved in the pathogenesis of JMML in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool
Share to Infant
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myelodysplastic Syndromes

Share to Neurofibromatosis 1

Share to Neurofibromin 1

Share to Proteins

Source

Identifiers

PMID: 9639526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.PMID 9639526Read ↗

Analysis of neurofibromatosis type 1 gene mutation in juvenile chronic myelogenous leukemia.Semantic proximity Read ↗

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorderSemantic proximity Read ↗

Biallelic inactivation of the NF1 tumour suppressor gene in juvenile myelomonocytic leukaemia: Genetic evidence of driver function and implications for diagnostic workup.Semantic proximity Read ↗

Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders.Semantic proximity Read ↗

Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders.Semantic proximity Read ↗

p53 mutation as the second event in juvenile chronic myelogenous leukemia in a patient with neurofibromatosis type 1.Semantic proximity Read ↗

Current management of juvenile myelomonocytic leukemia and the impact of RAS mutations.Semantic proximity Read ↗

Loss of heterozygosity of NF1 gene in juvenile chronic myelogenous leukemia with neurofibromatosis type 1.Semantic proximity Read ↗

Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.Semantic proximity Read ↗

Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.Semantic proximity Read ↗

Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia.Semantic proximity Read ↗

Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.