Article
Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders.
Blood - 1 Dec 1996
Miles D K, Freedman M H, Stephens K, Pallavicini M, Sievers E L, Weaver M, Grunberger T, Thompson P, Shannon K M
Abstract excerpt
Children with neurofibromatosis type 1 (NF1) are at increased risk of developing malignant myeloid disorders, particularly juvenile chronic myelogenous leukemia/juvenile myelomonocytic leukemia (JCML/JMML). We investigated bone marrows from 11 such patients (8 boys and 3 girls) and detected allel...
Topics
- Acute Disease
- Alleles
- Antigens, CD34
- Bone Marrow
- Cell Line, Transformed
- Cell Lineage
- Cell Transformation, Neoplastic
- Child
- Child, Preschool
- Disease Susceptibility
- Erythroid Precursor Cells
- Female
- Fetal Hemoglobin
- Gene Deletion