Article
Loss of heterozygosity of NF1 gene in juvenile chronic myelogenous leukemia with neurofibromatosis type 1.
International journal of hematology - 1 Jul 1998
Kai S, Sumita H, Fujioka K, Takahashi H, Hanzawa N, Funabiki T, Ikuta K, Sasaki H
Abstract excerpt
To investigate a genetic relation between juvenile chronic myelogenous leukemia (JCML) and neurofibromatosis type 1 (NF-1), we analyzed the NF1 gene in the leukemic cells of a JCML patient with NF-1. We found a point mutation in exon 29 of one allele and a deletion of the other normal allele in t...
Topics
- Alleles
- Genes, Neurofibromatosis 1
- Humans
- Infant
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Loss of Heterozygosity
- Male
- Point Mutation
- Polymerase Chain Reaction