Article
Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders.
The New England journal of medicine - 3 Mar 1994
Shannon K M, O'Connell P, Martin G A, Paderanga D, Olson K, Dinndorf P, McCormick F
Abstract excerpt
BACKGROUND: Children with type 1 neurofibromatosis (NF-1) are at increased risk for malignant myeloid disorders. Analysis of the NF-1 gene (NF1) suggests that the function of its product, neurofibromin, is reduced in affected persons and that NF1 belongs to the tumor-suppressor class of recessive...
Topics
- Alleles
- Base Sequence
- Bone Marrow
- Child
- Child, Preschool
- DNA Primers
- DNA, Neoplasm
- Female
- Gene Deletion
- Genes, Neurofibromatosis 1
- Heterozygote
- Humans
- Infant
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myelomonocytic, Chronic