Article
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.
Blood - 27 Aug 2009
Loh Mignon L, Sakai Debbie S, Flotho Christian, Kang Michelle, Fliegauf Manfred, Archambeault Sophie, Mullighan Charles G, Chen Leslie, Bergstraesser Eva, Bueso-Ramos Carlos E, Emanuel Peter D, Hasle Henrik, Issa Jean-Pierre, van den Heuvel-Eibrink Marry M, Locatelli Franco, Stary Jan, Trebo Monica, Wlodarski Marcin, Zecca Marco, Shannon Kevin M, Niemeyer Charlotte M
Abstract excerpt
Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Seventy-five percent of patients harbor mutations in the NF1, NRAS, KRAS, or PTPN11 genes, which encode components of Ras signaling networks. Using single nucleotide polymorphism arrays, we identified a...
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