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Article

Generation of an Allelic Series at the Ahr Locus Using an Edited Recombinant Approach.

Toxicological sciences : an official journal of the Society of Toxicology - 12 Apr 2021

Wilson Rachel H, Carney Patrick R, Glover Edward, Parrott Jessica C, Rojas Brenda L, Moran Susan M, Yee Jeremiah S, Nukaya Manabu, Goetz Nicholas A, Rubinstein Clifford D, Krentz Kathy J, Xing Yongna, Bradfield Christopher A

Abstract excerpt

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and a member of the PER-ARNT-SIM (PAS) superfamily of environmental sensors. The AHR is involved in a series of biological processes including adaptive metabolism of xenobiotics, toxicity of certain environmental pollutants, vascular development, fertility, and immune function. Mouse models, including the Ahr null and Ahr conditional...

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PMID: 33480436
DOI: 10.1093/toxsci/kfab005
PMCID: PMC8041461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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