Bacillus Calmette Guerin triggers the IL-12/IFN-gamma axis by an IRAK-4- and NEMO-dependent, non-cognate interaction between monocytes, NK, and T lymphocytes.

doi:10.1002/eji.200425221

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Bacillus Calmette Guerin triggers the IL-12/IFN-gamma axis by an IRAK-4- and NEMO-dependent, non-cognate interaction between monocytes, NK, and T lymphocytes.

European journal of immunology - 1 Nov 2004

Feinberg Jacqueline, Fieschi Claire, Doffinger Rainer, Feinberg Max, Leclerc Tony, Boisson-Dupuis Stéphanie, Picard Capucine, Bustamante Jacinta, Chapgier Ariane, Filipe-Santos Orchidée, Ku Cheng-Lung, de Beaucoudrey Ludovic, Reichenbach Janine, Antoni Guillemette, Baldé Ramatoulaye, Alcaïs Alexandre, Casanova Jean-Laurent

Abstract excerpt

The IL-12/IFN-gamma axis is crucial for protective immunity to Mycobacterium in humans and mice. Our goal was to analyze the relative contribution of various human blood cell subsets and molecules to the production of, or response to IL-12 and IFN-gamma. We designed an assay for the stimulation of whole blood by live M. bovis Bacillus Calmette-Guerin (BCG) alone, or BCG plus IL-12 or IFN-gamma, measuring...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to I-kappa B Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1 Receptor-Associated Kinases

Share to Interleukin-12

Share to Interleukin-12 Subunit p40

Share to Lymphocyte Subsets

Share to Monocytes

Share to Mycobacterium bovis

Share to Phosphotransferases (Alcohol Group Acceptor)

Source

Open in PubMed

Identifiers

PMID: 15384045
DOI: 10.1002/eji.200425221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bacillus Calmette Guerin triggers the IL-12/IFN-gamma axis by an IRAK-4- and NEMO-dependent, non-cognate interaction between monocytes, NK, and T lymphocytes.PMID 15384045Read ↗

Defects in the interferon-gamma and interleukin-12 pathways.Semantic proximity Read ↗

Impaired interferon gamma-mediated immunity and susceptibility to mycobacterial infection in childhood.Semantic proximity Read ↗

Human interferon-gamma-mediated immunity is a genetically controlled continuous trait that determines the outcome of mycobacterial invasion.Semantic proximity Read ↗

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production.Semantic proximity Read ↗

Interferon-gamma and interleukin-12 pathway defects and human disease.Semantic proximity Read ↗

Inherited disorders of the IL-12-IFN-gamma axis in patients with disseminated BCG infection.Semantic proximity Read ↗

Control of human host immunity to mycobacteria.Semantic proximity Read ↗

Gamma interferon is dispensable for neopterin production in vivo.Semantic proximity Read ↗

Mendelian susceptibility to mycobacterial infection in man.Semantic proximity Read ↗

Human CD56bright and CD56dim natural killer cell subsets respond differentially to direct stimulation with Mycobacterium bovis bacillus Calmette-Guérin.Semantic proximity Read ↗

Association of polymorphisms in IL-12/IFN-gamma pathway genes with susceptibility to pulmonary tuberculosis in Indonesia.Semantic proximity Read ↗

Stimulation of neutrophil granulocytes with Mycobacterium bovis bacillus Calmette-Guérin induces changes in phenotype and gene expression and inhibits spontaneous apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.