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Article

A role for IL-18 in protective immunity against Mycobacterium tuberculosis.

European journal of immunology - 1 Feb 2010

Schneider Bianca E, Korbel Daniel, Hagens Kristine, Koch Markus, Raupach Bärbel, Enders Jana, Kaufmann Stefan H E, Mittrücker Hans-Willi, Schaible Ulrich E

Abstract excerpt

Tuberculosis remains the most hazardous bacterial infection worldwide. The causative agent, Mycobacterium tuberculosis, is a facultative intracellular pathogen of resting MPhi. IFN-gamma secreted by natural killer, CD4 Th 1 and CD8 T cells upon instruction by IL-12 and -18 activates MPhi to restrict mycobacterial growth. Production of both cytokines is induced by TLR signalling in DC and MPhi. Mice deficient for...

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Identifiers

PMID: 19950174
DOI: 10.1002/eji.200939583
PMCID: PMC3189623

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