Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of interleukin-12 in human infectious diseases: only a faint signature.

European journal of immunology - 1 Jun 2003

Fieschi Claire, Casanova Jean-Laurent

Abstract excerpt

IL-12 is the signature IFN-gamma-inducing cytokine and, as such, is thought to be crucial for protective immunity against intracellular microorganisms. This concept is supported by results from experimental infections of knockout mice lacking IL-12 or the IL-12 receptor. The description of human patients with inherited IL-12 or IL-12-receptor deficiency challenges this view. Indeed, in natural conditions of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BCG Vaccine
Share to Infections
Share to Interleukin-23

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mycobacterium bovis

Share to Mycobacterium Infections

Share to Receptors, Interleukin-12

Share to Salmonella Infections

Share to Salmonella Infections, Animal

Source

Identifiers

PMID: 12778462
DOI: 10.1002/eji.200324038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of interleukin-12 in human infectious diseases: only a faint signature.PMID 12778462Read ↗

Defects in the interferon-gamma and interleukin-12 pathways.Semantic proximity Read ↗

IL-12 Family Cytokines: General Characteristics, Pathogenic Microorganisms, Receptors, and Signalling PathwaysSemantic proximity Read ↗

Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity.Semantic proximity Read ↗

Human deficiencies in type 1 cytokine receptors reveal the essential role of type 1 cytokines in immunity to intracellular bacteria.Semantic proximity Read ↗

Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria.Semantic proximity Read ↗

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients.Semantic proximity Read ↗

Innate defects of the IL-12/IFN-γ axis in susceptibility to infections by mycobacteria and salmonella.Semantic proximity Read ↗

Primary immunodeficiencies of protective immunity to primary infections.Semantic proximity Read ↗

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency.Semantic proximity Read ↗

Interferon-gamma and interleukin-12 pathway defects and human disease.Semantic proximity Read ↗

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.Semantic proximity Read ↗

What We Have Here Is a Failure to Communicate: Interleukin-12 / Interferon-gamma Axis Defects and Mendelian Susceptibility to Mycobacterial Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.