Article
Lack of beta-amyloid production in M19 cells deficient in site 2 processing of the sterol regulatory element binding proteins.
FEBS letters - 15 May 1998
Manni M E, Cescato R, Paganetti P A
Abstract excerpt
The processing of the amyloid precursor protein (APP) and the sterol regulatory element binding protein show remarkable analogies. Following a first lumenal cleavage, both proteins undergo a cleavage within the transmembrane domain by enzymatic activities named gamma-secretase and S2P, respective...
Topics
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Aspartic Acid Endopeptidases
- Biological Transport
- CCAAT-Enhancer-Binding Proteins
- CHO Cells
- Cricetinae
- DNA-Binding Proteins
- Endopeptidases
- Glycosylation
- Humans
- Mutation
- Nuclear Proteins
- Protein Processing, Post-Translational
- Sterol Regulatory Element Binding Protein 1
- Transcription Factors