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Article

Lack of beta-amyloid production in M19 cells deficient in site 2 processing of the sterol regulatory element binding proteins.

FEBS letters - 15 May 1998

Manni M E, Cescato R, Paganetti P A

Abstract excerpt

The processing of the amyloid precursor protein (APP) and the sterol regulatory element binding protein show remarkable analogies. Following a first lumenal cleavage, both proteins undergo a cleavage within the transmembrane domain by enzymatic activities named gamma-secretase and S2P, respectively. We analyzed the processing of APP in the mutant Chinese hamster ovary (CHO) cell line M19 which lacks the S2P gene...

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Source

Identifiers

PMID: 9637259
DOI: 10.1016/s0014-5793(98)00469-4

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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