Article
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
The Journal of cell biology - 1 Apr 1993
De Strooper B, Umans L, Van Leuven F, Van Den Berghe H
Abstract excerpt
Amyloid precursor protein (APP) secretase plays a pivotal role in the processing of APP since its activity precludes the formation of amyloid peptide in Alzheimer's Disease. The identity and the subcellular localization of this enzyme are at this moment unknown. It is also unclear how APP escapes...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Animals
- Arginine
- Asparagine
- Aspartic Acid Endopeptidases
- Base Sequence
- Cell Compartmentation
- Cell Line
- Endopeptidases
- Methylamines
- Mice