Ultraviolet-light induced p53 mutational spectrum in yeast is indistinguishable from p53 mutations in human skin cancer.

doi:10.1093/carcin/19.5.741

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Article

Ultraviolet-light induced p53 mutational spectrum in yeast is indistinguishable from p53 mutations in human skin cancer.

Carcinogenesis - 1 May 1998

Inga A, Scott G, Monti P, Aprile A, Abbondandolo A, Burns P A, Fronza G

Abstract excerpt

Ultraviolet (UV) light has been associated with the development of human non-melanoma skin cancers (NMSC). Such cancers often exhibit mutations in the p53 tumour suppressor gene. In order to determine the UV-induced p53 mutation spectrum, a yeast expression vector that harbours a human wild-type...

Topics

DNA, Complementary
Genes, p53
Humans
Melanoma
Mutation
Neoplasms, Radiation-Induced
Saccharomyces cerevisiae
Skin Neoplasms
Tumor Suppressor Protein p53
Ultraviolet Rays

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