Article
The specificity of p53 mutation spectra in sunlight induced human cancers.
Journal of photochemistry and photobiology. B, Biology - 1 May 1995
Daya-Grosjean L, Dumaz N, Sarasin A
Abstract excerpt
Ultraviolet (UV) irradiation emitted by the sun has been clearly implicated as a major carcinogen in the formation of skin cancers in man. Indeed, the high levels of cutaneous tumors in xeroderma pigmentosum patients (XP) who are deficient in repair of UV-induced lesions have confirmed that DNA damage produced by sunlight is directly involved in the cancer development. The tumor suppressor gene, p53, very...
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