Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The specificity of p53 mutation spectra in sunlight induced human cancers.

Journal of photochemistry and photobiology. B, Biology - 1 May 1995

Daya-Grosjean L, Dumaz N, Sarasin A

Abstract excerpt

Ultraviolet (UV) irradiation emitted by the sun has been clearly implicated as a major carcinogen in the formation of skin cancers in man. Indeed, the high levels of cutaneous tumors in xeroderma pigmentosum patients (XP) who are deficient in repair of UV-induced lesions have confirmed that DNA damage produced by sunlight is directly involved in the cancer development. The tumor suppressor gene, p53, very...

Topics

Animals
Biomarkers, Tumor
DNA Mutational Analysis
DNA Repair
Genes, p53
Humans
Mutation
Neoplasms, Radiation-Induced
Pyrimidines
Skin Neoplasms
Sunlight
Ultraviolet Rays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Xeroderma Pigmentosum

Source

Identifiers

PMID: 7636632
DOI: 10.1016/1011-1344(95)07130-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7636632-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The specificity of p53 mutation spectra in sunlight induced human cancers.PMID 7636632Read ↗

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.Semantic proximity Read ↗

TP53 mutations in human skin cancers.Semantic proximity Read ↗

p53 gene mutations in human skin cancers.Semantic proximity Read ↗

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.Semantic proximity Read ↗

Mutational spectra of human cancer.Semantic proximity Read ↗

p53 mutations in skin and internal tumors of xeroderma pigmentosum patients belonging to the complementation group C.Semantic proximity Read ↗

p53 and the pathogenesis of skin cancer.Semantic proximity Read ↗

p53 mutational spectra and the role of methylated CpG sequences.Semantic proximity Read ↗

Carcinogen-specific mutation pattern in the p53 tumour suppressor gene in UV radiation-induced basal cell carcinoma.Semantic proximity Read ↗

Significance of CpG Methylation for Solar UV‐Induced Mutagenesis and Carcinogenesis in Skin<sup>‡</sup>Semantic proximity Read ↗

Strand specificity and absence of hot spots for p53 mutations in ultraviolet B-induced skin tumors of XPA-deficient mice.Semantic proximity Read ↗

The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.