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Article

Associations of Alzheimer Disease-Protective APOE Variants With Age-Related Macular Degeneration.

JAMA ophthalmology - 1 Jan 2023

Rasmussen Katrine L, Tybjærg-Hansen Anne, Nordestgaard Børge G, Frikke-Schmidt Ruth

Abstract excerpt

Importance: The association of major lipid genes with and their potential as drug targets for age-related macular degeneration (AMD) is unknown. These associations are important to study because AMD is the leading cause of irreversible late-onset blindness in high-income countries. Objective: To determine whether the full range of structural genetic variation in apolipoprotein E (APOE), a master gene in...

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Identifiers

PMID: 36394841
DOI: 10.1001/jamaophthalmol.2022.4602
PMCID: PMC9673029

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