Article
ARMS test for diagnosis of factor V Leiden mutation and allele frequencies in France.
Molecular and cellular probes - 1 Apr 1998
Bathelier C, Champenois T, Lucotte G
Abstract excerpt
The authors have developed a simple and rapid amplification-refractory mutation system (ARMS) assay for the factor V Leiden mutation (MIM 227400.0001). Polymerase chain reaction (PCR) primers within exon 10 of the factor V gene were designed; one common upstream primer was paired with either a normal or a mutant-specific downstream primer. The assay was validated using factor V Leiden DNA samples of thrombophilic...
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