Article
Rapid detection and prenatal diagnosis of beta-thalassaemia: studies in Indian and Cypriot populations in the UK.
Lancet (London, England) - 6 Oct 1990
Old J M, Varawalla N Y, Weatherall D J
Abstract excerpt
The application of the amplification refractory mutation system (ARMS) to the detection of individual beta-thalassaemia mutations in heterozygous parents and "at risk" fetuses has been assessed in Indian and Cypriot immigrant populations in the UK. 100 first trimester prenatal diagnoses have been done, entailing the detection of 17 different mutations. The method, which allows the determination of the mutations...
Topics
- Cyprus
- DNA
- Evaluation Studies as Topic
- Female
- Genetic Carrier Screening
- Humans
- India
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Pregnancy