Article
[Prevalence of thrombophilic mutations of FV Leiden, prothrombin G20210A and PAl-1 4G/5G and their combinations in a group of 1450 healthy middle-aged individuals in the Prague and Central Bohemian regions (results of FRET real-time PCR assay)].
Casopis lekaru ceskych - 1 Jan 2012
Kvasnicka Jan, Hájková Jaroslava, Bobcíková Petra, Kvasnicka Tomás, Dusková Daniela, Poletínová Sárka, Kieferová Veronika
Abstract excerpt
BACKGROUND: Factor V Leiden (G1691A) and prothrombin gene (FII G20210A) mutations are independent risk factors of venous thrombosis and this risk is further increased by the combined genotype 4G/4G PAI-1. AIM: The primary objective was to identify the frequency of mutations of minor alleles and genotypes of FVL, FII G20210A and PAI-1 4G/5G in healthy Caucasians in the Prague and Central Bohemia regions. The...
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