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Article

Thyrotropin, follitropin, and chorionic gonadotropin expressed as a single multifunctional unit reveal remarkable permissiveness in receptor-ligand interactions.

Endocrinology - 1 Oct 2002

Garcia-Campayo Vicenta, Kumar T Rajendra, Boime Irving

Abstract excerpt

The glycoprotein hormones [chorionic gonadotropin (CG), FSH, LH, and TSH] are composed of a common alpha-subunit and a hormone-specific beta-subunit. Subunit assembly is vital to the in vivo function of these hormones. However, recent in vitro studies using double domain (beta-alpha) and triple domain (beta-beta-alpha) single chains have shown that gonadotropin receptor recognition can accommodate...

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Identifiers

PMID: 12239087
DOI: 10.1210/en.2002-220336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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