Article
Promoter analysis of the human mismatch repair gene hMSH2.
Gene - 15 Jun 1998
Iwahashi Y, Ito E, Yanagisawa Y, Akiyama Y, Yuasa Y, Onodera T, Maruyama K
Abstract excerpt
The human DNA mismatch repair gene homologue hMSH2 is involved in hereditary nonpolyposis colorectal cancer. We isolated and characterized the 5' upstream region, about 4.4kbp, of the hMSH2 gene. This region contains CpG islands and a number of elements involved in constitutive expression, but there is no TATA-box nearby the transcription start points. This is the typical structure for many promoters of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
