Article
Isolation and characterization of the 5' region of the human mismatch repair gene hPMS1.
Biochemical and biophysical research communications - 24 Feb 1998
Yanagisawa Y, Ito E, Iwahashi Y, Akiyama Y, Yuasa Y, Maruyama K
Abstract excerpt
The hPMS1 gene encodes a mutL homolog that is implicated in DNA mismatch repair and was found to be mutated in the germline of a patient with hereditary nonpolyposis colorectal cancer (HNPCC). To understand transcriptional regulation and to perform mutational analysis in the promoter region, we c...
Topics
- Alleles
- Alternative Splicing
- Base Sequence
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Mutational Analysis
- DNA Primers
- DNA Repair
- DNA, Complementary
- Gene Expression Regulation, Neoplastic
- Gene Frequency
- Humans
- Molecular Sequence Data
- MutL Proteins
- Neoplasm Proteins
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Restriction Mapping
- Sequence Analysis, DNA