Article
Intron splice acceptor site sequence variation in the hereditary non-polyposis colorectal cancer gene hMSH2.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1994
Hall N R, Taylor G R, Finan P J, Kolodner R D, Bodmer W F, Cottrell S E, Frayling I, Bishop D T
Abstract excerpt
Common but weakly penetrant mutations of certain genes may confer an increased susceptibility to colorectal cancer and account for a proportion of 'sporadic' cases. We analysed DNA from 111 colorectal cancer cases and 114 controls for a specific candidate sequence variation in the hereditary non-...
Topics
- Adolescent
- Adult
- Base Sequence
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA, Neoplasm
- Disease Susceptibility
- Female
- Genotype
- Humans
- Introns
- Male
- Molecular Sequence Data
- Pedigree
- Phenotype
- Polymorphism, Genetic