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Article

Intron splice acceptor site sequence variation in the hereditary non-polyposis colorectal cancer gene hMSH2.

European journal of cancer (Oxford, England : 1990) - 1 Jan 1994

Hall N R, Taylor G R, Finan P J, Kolodner R D, Bodmer W F, Cottrell S E, Frayling I, Bishop D T

Abstract excerpt

Common but weakly penetrant mutations of certain genes may confer an increased susceptibility to colorectal cancer and account for a proportion of 'sporadic' cases. We analysed DNA from 111 colorectal cancer cases and 114 controls for a specific candidate sequence variation in the hereditary non-polyposis colorectal cancer gene hMSH2. The variant sequence was found in a quarter of individuals, and there was no...

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PMID: 7833117
DOI: 10.1016/0959-8049(94)00326-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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