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Article

A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1.

Biochemical and biophysical research communications - 24 Mar 1999

Ito E, Yanagisawa Y, Iwahashi Y, Suzuki Y, Nagasaki H, Akiyama Y, Sugano S, Yuasa Y, Maruyama K

Abstract excerpt

The hMLH1 gene encodes a protein that is involved in the DNA mismatch repair system. The coding region of the hMLH1 gene has been known to be mutated in a subset of patients with hereditary nonpolyposis colorectal cancer (HNPCC). Our current research characterized the promoter region of the hMLH1 gene and searched for mutations correlating to HNPCC. Utilizing the oligo-capping method, major transcription start...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10080925
DOI: 10.1006/bbrc.1999.0368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1.PMID 10080925Read ↗

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Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC)Semantic proximity Read ↗

Reduced frequency of extracolonic cancers in hereditary nonpolyposis colorectal cancer families with monoallelic hMLH1 expression.Semantic proximity Read ↗

Promoter analysis of the human mismatch repair gene hMSH2.Semantic proximity Read ↗

Gene symbol: hMLH1. Disease: Hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

A hMLH1 genomic mutation and associated novel mRNA defects in a hereditary non-polyposis colorectal cancer family.Semantic proximity Read ↗

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