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Single nucleotide polymorphism detection in the hMSH2 gene using conformation-sensitive CE.

Electrophoresis - 1 Feb 2008

Chen Yen-Ling, Jong Yuh-Jyh, Ferrance Jerome, Hsien Jan-Sing, Shih Chi-Jen, Feng Chia-Hsien, Wu Ming-Tsang, Wu Shou-Mei

Abstract excerpt

CE allows for highly reproducible analysis of DNA fragments which can be used to detect DNA mutations including SNPs. We have utilized a simple and direct CE analysis method for SNP analysis called conformation-sensitive CE (CSCE), based on the principle of single nucleotide different to produce conformational changes in the mildly denaturing solvent system. This method was applied to analysis of a mutation in...

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PMID: 18186537
DOI: 10.1002/elps.200700488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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