Article
Paget's disease of bone: evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 1998
Haslam S I, Van Hul W, Morales-Piga A, Balemans W, San-Millan J L, Nakatsuka K, Willems P, Haites N E, Ralston S H
Abstract excerpt
Paget's disease of bone is a common condition characterized by bone pain, deformity, pathological fracture, and an increased incidence of osteosarcoma. Genetic factors play a role in the pathogenesis of Paget's disease but the molecular basis of the disease remains unclear. Previous genetic linkage studies have mapped the rare Paget's disease-like bone dysplasia familial expansile osteolysis (FEO) to chromosome...
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