Article
Genetic determinants of Paget's disease of bone.
Annals of the New York Academy of Sciences - 1 Dec 2011
Ralston Stuart H, Albagha Omar M E
Abstract excerpt
Paget's disease is a common skeletal disorder with a strong genetic component, which is characterized by focal increases in disorganized bone remodeling, predominantly affecting the axial skeleton. Current evidence suggests that classical Paget's disease of bone (PDB) is caused by a combination of rare alleles of large effect size that cause autosomal dominant inheritance of the disease and more common alleles of...
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