Article
Variable disease severity associated with a Paget's disease predisposition gene.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 1999
Leach R J, Singer F R, Cody J D, Roodman G D
Abstract excerpt
We have recently identified a region on the long arm of chromosome 18 that carries a predisposition gene for Paget's disease using linkage analysis. This region was explored because of earlier studies demonstrating the presence of a gene for another bone disorder, familial expansile osteolysis (FEO) within this region. FEO has many similarities to Paget's disease including osteoclast abnormalities and viral-like...
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