Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Linkage of Paget disease of bone to a novel region on human chromosome 18q23.

American journal of human genetics - 1 Feb 2002

Good David A, Busfield Frances, Fletcher Barbara H, Duffy David L, Kesting Janine B, Andersen John, Shaw Joanne T E

Abstract excerpt

Paget disease of bone (PDB) is characterized by increased osteoclast activity and localized abnormal bone remodeling. PDB has a significant genetic component, with evidence of linkage to chromosomes 6p21.3 (PDB1) and 18q21-22 (PDB2) in some pedigrees. There is evidence of genetic heterogeneity, with other pedigrees showing negative linkage to these regions. TNFRSF11A, a gene that is essential for osteoclast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 18

Share to Chromosomes, Human, Pair 7

Share to Haplotypes

Share to Lod Score

Share to Osteitis Deformans

Share to Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 11742440
DOI: 10.1086/338658
PMCID: PMC384924

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linkage of Paget disease of bone to a novel region on human chromosome 18q23.PMID 11742440Read ↗

Familial Paget's disease of bone: nonlinkage to the PDB1 and PDB2 loci on chromosomes 6p and 18q in a large pedigree.Semantic proximity Read ↗

Genetic linkage of Paget disease of the bone to chromosome 18q.Semantic proximity Read ↗

Paget's disease of bone: evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity.Semantic proximity Read ↗

Paget disease of bone: mapping of two loci at 5q35-qter and 5q31.Semantic proximity Read ↗

Genetics of Paget's disease of bone.Semantic proximity Read ↗

Mechanisms of disease: genetics of Paget's disease of bone and related disorders.Semantic proximity Read ↗

Biology and Treatment of Paget's Disease of Bone.Semantic proximity Read ↗

Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.Semantic proximity Read ↗

Genetics of Paget's disease of bone.Semantic proximity Read ↗

Genetic Determinants of Paget's Disease of Bone.Semantic proximity Read ↗

Genetics of Paget’s disease of boneSemantic proximity Read ↗

Familial Paget’s disease of bone: patterns of inheritance and frequency of linkage to chromosome 18qSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.