Article
Genetic linkage of Paget disease of the bone to chromosome 18q.
American journal of human genetics - 1 Nov 1997
Cody J D, Singer F R, Roodman G D, Otterund B, Lewis T B, Leppert M, Leach R J
Abstract excerpt
Paget disease is a common bone disease characterized by abnormal osteoclasts that are large, multinucleated, and overactive and that contain paramyxovirus-like nuclear inclusions. There is evidence for a major genetic component to Paget disease, with up to 40% of patients having affected first-degree relatives; however, the locus (loci) and gene(s) involved are unknown. Another bone disorder, familial expansile...
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